Starring Lorenza Izzo, Bryan Craig, Chrissie Fit, Simu Liu, Steven Bauer, Liza Weil, Cranston Johnson, Alejandra Miranda, Shalim Ortiz and Lincoln Bonilla, it follows the life of a young woman from her formative years to adulthood in 1960s San Francisco.

In 1967 San Francisco, Celina Guerrera is a studious teenager who attends a Catholic high school and is from a conservative immigrant family.

In February 2019, Deadline Hollywood announced Lorenza Izzo would star in the feminist indie drama written and directed by Lissette Feliciano in her feature directorial debut.

[6] Women Is Losers holds a 72% approval rating on the review aggregator website Rotten Tomatoes, whose consensus reads: "While it might have benefited from a subtler approach to its message, Women Is Losers is elevated by outstanding work from lead Lorenza Izzo.

"[7] Kate Erbland of IndieWire gave the film a B−, writing Women Is Losers “is an infectious and auspicious debut…surely the start of something wonderful for [Lissette] Feliciano”.