[4] In September 2021, it was announced that IBM transferred ownership to the Krembil Research Institute of University Health Network in Toronto, Ontario.

[5] World Community Grid uses unused processing power of consumer devices (PCs, Laptops, Android Smartphones, etc.)

[16] Based on the success of the Smallpox study, IBM announced the creation of World Community Grid on November 16, 2004, with the goal of creating a technical environment where other humanitarian research could be processed.

[21] The World Community Grid software uses the unused computing time of Internet-connected devices to perform research calculations.

The WCG servers disregard statistical outliers, average the remaining values and award the resulting number of points to each computer.

The project runs on CPUs and GPUs and will also serve to create a "fast-response, open source tool that will help all scientists quickly search for treatments for future pandemics.

By comparing these different data points, researchers aim to identify patterns of markers for different cancers and correlate them with different outcomes, including responsiveness to various treatment options.

[69] Devised by Richard Bonneau at the Institute for Systems Biology, the project used grid computing to produce the likely structures for each of the proteins using a Rosetta Score.

[72] Human Proteome Folding - Phase 2 (HPF2) (launched June 23, 2006[73]) was the third project to run on World Community Grid, and completed in 2013.

The HPF2 results helped Dr. Markus Landthaler and his collaborators in writing up a new paper on "The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts"[75] The Help Defeat Cancer project seeks to improve the ability of medical professionals to determine the best treatment options for patients with breast, head, or neck cancer.

The database of information produced will help researchers design molecules to inhibit or enhance binding of particular macromolecules, hopefully leading to better treatments for muscular dystrophy and other neuromuscular diseases.

World Community Grid's tremendous computing power was used to understand and reduce the uncertainty with which climate processes were simulated over Africa.

[citation needed] The Nutritious Rice for the World project is carried out by Ram Samudrala's Computational Biology Research Group at the University of Washington.

[90] The purpose of this project is to predict the structure of proteins of major strains of rice, in order to help farmers breed better rice strains with higher crop yields, promote greater disease and pest resistance, and utilize a full range of bioavailable nutrients that can benefit people around the world, especially in regions where malnutrition is a critical concern.

These results – which were only possible because of the massive amount of donated computing power they had available – are expected to guide future research and plant science efforts.

Researchers are employing molecular mechanics and electronic structure calculations to predict the optical and transport properties of molecules that could become the next generation of solar cell materials.

[94] By harnessing the computing power of the World Community Grid, researchers were able to calculate the electronic properties of tens of thousands of organic materials – many more than could ever be tested in a lab – and determine which candidates are most promising for developing affordable solar energy technology.

[93] Further calculations about optical, electronic and other physical properties of the candidate materials are being conducted with the Q-Chem quantum chemistry software.

[100] The mission of the Help Fight Childhood Cancer project is to find drugs that can disable three particular proteins associated with neuroblastoma, one of the most frequently occurring solid tumors in children.

[105] World Community Grid and researchers supported by Decrypthon, a partnership between AFM (French Muscular Dystrophy Association), CNRS (French National Center for Scientific Research), Universite Pierre et Marie Curie, and IBM were investigating protein–protein interactions for more than 2,200 proteins whose structures are known, with particular focus on those proteins that play a role in neuromuscular diseases.

The database of information produced will help researchers design molecules to inhibit or enhance binding of particular macromolecules, hopefully leading to better treatments for muscular dystrophy and other neuromuscular diseases.

The mission is to identify promising drug candidates to combat the Dengue, Hepatitis C, West Nile, Yellow Fever, and other related viruses.

[110] Computing for Clean Water (launched September 20, 2010[111][112]) is sponsored by the Center for Nano and Micro Mechanics of Tsinghua University in Beijing.

The project's mission is to provide deeper insight on the molecular scale into the origins of the efficient flow of water through a novel class of filter materials.

The best compounds will be tested by scientists at The Scripps Research Institute in La Jolla, California, U.S.A. and further developed into possible treatments for the disease.

The researchers at Infórium University in Belo Horizonte and FIOCRUZ-Minas, Brazil, ran this project on World Community Grid to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins in the hope of finding effective treatments for schistosomiasis.

The researchers at the University of Virginia were running this project on World Community Grid to study the effects of human activity on a large watershed and gain deeper insights into what actions can support the restoration, health and sustainability of this important water resource.

[125] The aim is to block crucial steps in the life cycle of the virus, by finding drugs with high binding affinity with certain of its proteins.

[129] FightAIDS@Home (launched November 19, 2005[130]) was World Community Grid's second project and its first to target a single disease.

[139][140] Upon Dr. Akira Nakagawara's retirement in March 2020, the principal investigator changed to Dr. Godfrey Chan, who was one of the original members of the Smash Childhood Cancer team.