Wu Ken started his diplomatic career in the personnel department of the Ministry of Foreign Affairs.

After attending a postgraduate course at the University of Frankfurt, Wu Ken worked as an Attaché of the Ministry of Foreign Affairs in the department of Soviet- and Eurasian affairs.

From 1993 to 1998, Wu Ken occupied the following posts: 3rd secretary, assistant sector leader and sector leader of the personnel department of the Ministry of Foreign Affairs.

Between October 2007 and August 2010, Wu Ken was China's ambassador to Austria.

He was appointed as a member of the 14th Chinese People's Political Consultative Conference on 17 January 2023 from the Friendship with Foreign Countries Sector.