2 High School (simplified Chinese: 上海市第二中学; traditional Chinese: 上海市第二中學) is a public secondary school located in Shanghai, China.

Founded in 1902 by Wu Xin as Wu Pen Girls' School (simplified Chinese: 务本女塾; traditional Chinese: 務本女塾),[1] Shanghai No.2 High School holds the distinction of being the first independent girls' school established by Chinese nationals in the 20th century.

In 1947, the school relocated to 200 Yongkang Road (formerly 209 Route Remi),[2] occupying the former campus of Ecole Primaire Russe (俄國初級小學), which was later renamed and known as Ecole Municipale Française-Ecole Rémy (法國雷米小學).

In 1952, Wu Pen Girls' School was renamed Shanghai No.

In September 1967, the institution transitioned into a co-educational public school and was renamed Shanghai No.