She served as a civil servant who worked at the South Jakarta Health Department from 1995 to 2019, and previously held the position of Treasurer of the Indonesian Dental Nurses Association from 2005 to 2010.

This experience provided her with valuable insights into the health needs of her community and helped to further develop her skills and dedication to public service.

The wedding was attended by many prominent figures from politics and society, including former Vice President Jusuf Kalla and former Minister of Economy Hatta Rajasa, who served as witnesses.

As the wife of the Vice President, Handayani has had the opportunity to represent Indonesia in various international events and has used this platform to promote the country's culture and heritage.

Her commitment to public service and dedication to making a positive impact on the lives of others have made her a respected and admired figure in her community.