It serves the western Melbourne suburb of Manor Lakes, which was part of Wyndham Vale until being gazetted as a separate suburb in March 2016, nine months after the station opened.

[1] Built as part of the Regional Rail Link project,[2][3] it was officially opened on 14 June 2015 by Premier Daniel Andrews and the federal Minister for Infrastructure and Regional Development, Warren Truss, with services commencing on 21 June 2015.

[4] A turnback siding is located between the two running lines just to the south of the station, used for peak hour terminating services from Melbourne.

[5] Under the Western Rail Plan, announced by the Andrews State Government in 2018, the station will eventually become part of the metropolitan railway network.

[7][8] Platform 1: Platform 2: CDC Melbourne operate four bus routes via Wyndham Vale station, under contract to Public Transport Victoria: