The Wyna is started by several headwaters south-west of Neudorf (LU) in the Lindewald (forest), 17 km north-east from Lucerne.
Near Underdorf, the Lochbach, or Hole Creek, which starts in the Chegelwald, west of Neudorf, joins the Wyna.
Then, it runs north through Beromünster (still canton of Lucerne), through Menziken and Reinach (now in canton of Aargau), west of Zetzwil, through Oberkulm and Unterkulm, through Teufenthal (AG), and through Gränichen before joining the Suhre at 385m in Suhr, which joins the Aare further north, just three kilometres later.
The valley, the Wynetal (or Germanized also known as Wynental), is fairly narrow, with an average width of about 500 meters, and drops very smoothly from 670m a.s.l.
This road is referred to variously as Aargauerstrasse, Hauptstrasse, Aarauerstrasse, Wynentalstrasse, and numerous names north of Teufenthal and is a popular cycling route.