Wyocena is a village in Columbia County, Wisconsin, United States.

A tornado struck the village on April 25, 2008, destroying several homes.

Wis 16 heads east to Columbus and west to Poynette and Portage.

There were 296 housing units at an average density of 208.5 per square mile (80.5/km2).

31.7% of all households were made up of individuals, and 8.1% had someone living alone who was 65 years of age or older.

There were 241 housing units at an average density of 168.2 per square mile (65.1/km2).

27.9% of all households were made up of individuals, and 11.1% had someone living alone who was 65 years of age or older.