Development in Wyoming then shifted towards the southwest panhandle near RiverTown Crossings in the early 21st century and has continued in the area surrounding Metro Health Hospital following its opening in 2007, though General Motors closed the stamping plant two years later in 2009.

[7] Where what is now Grandville, Michigan, a prairie existed west of Wyoming where up to ten native families under the ogema As-to-quet, who were friendly with early settlers in the area, held planting grounds.

[13] The first settlers had a successful harvest, constructing gristmills and sawmills on Buck Creek in a year in 1833 and by April 1834, a community called "Little Prairie" had been established.

[10][16] It was this year that one of Wyoming's most notable pioneers, Justus Charles Rogers, established his homestead on what is now the southwest corner of 28th Street and Clyde Park Avenue.

[19] In 1839, the township's final land patents south of the Grand River were issued for plots near the salt springs adjacent to the Norton Mounds and Section 16.

[21] Operations for Fisher would expand further south on Buck Creek where he would extract lime and peat, later building a second mill on a plot of land he purchased from William Ferry in the southeast portion of the township.

[31] From 1890 to 1906, thirty-two plats were in the GUB neighborhoods with communities bordering Grand Rapids developing into suburban areas where Dutch Americans predominately resided.

[31] The growth of Wyoming saw the emergence of profitable businesses there, including the Leonard Refrigerator Company, the Pierre Marquette railroad car repair shop and gypsum mines.

[34] Into the 1920s, Wyoming saw its population nearly triple, experiencing its period of largest growth, with city officials accustomed to rural affairs being overwhelmed with new developments, taking on tasks and issues as they occurred.

[40][36] One major incident of Grand Rapids preventing industrial development in Wyoming occurred in the early 1920s when Ford Motor Company attempted to purchase the unfinished picric acid factory that was being constructed during World War I.

[41][36] As the Great Depression affected the world's economy in the 1930s, Grand Rapids saw little industrial development as there was no demand for luxury furniture, the city's main economic product.

[49] Former Mayor of Grand Rapids George P. Tilma was elected supervisor of Wyoming Township in 1932 and was tasked with modernizing the developing suburban community from a rural town system.

[51] In the winter of 1933, Tilma was also able to circumvent the Emergency Banking Act in a technicality to purchase 555 tons of coal that was distributed to the poor to heat their homes.

[36] Tilma's expertise was instrumental in both secretly negotiating with Grand Rapids on utility work and with obtaining approval of the site by General Motors.

[31] Following World War II, Wyoming developed so rapidly that mobile homes began to appear on vacant properties throughout the city, with an ordinance being passed in 1947 to prevent this.

[43] In 1946, General Motors Diesel Equipment Division, which was later known as Delphi Automotive and today known as GM Components Holdings, began operations in an area of 45 acres (180,000 m2) that was former swampland which was drained for a muck farm.

[56] One major project was Rogers Plaza, which opened in August 1961 as the first indoor shopping mall in Michigan and one of the first in the United States, including stores such as S. S. Kresge, W. T. Grant, Kroger, A&P, Cunningham Drug, and Montgomery Ward.

[58] In July 1966, the Lake Michigan pipeline to Wyoming began to supply water to the city, a major accomplishment after years of difficulties with low-quality wells.

[62] A street was also planned to stretch from Rogers Plaza across Michael Avenue to Wyoming Village Mall and further down to Studio 28, with commercial and apartment developments anticipated.

[56] More business was lost in the late-2000s into the 2010s during the great recession, with the GM Fisher Body Plant closing in 2009 due to budget cuts by General Motors.

The 28 West plan was also initiated to make 28th Street a more pedestrian-friendly corridor while also centralizing the development of food, retail, and entertainment projects in the city's center, effectively creating a downtown area.

[69][70] In 2019, Magnus Capital Partners was approved to construct apartments, named HōM Flats at 28 West, with the first residents moving into their homes in early 2020.

[71][72] In 2022, Franklin Partners purchased the former land of the General Motors plant, known as Site 36, from the City of Wyoming for $5.25 million and started development discussions with four local companies and a few entities based outside of Michigan.

[29] Some areas in Wyoming had caverns and sinkholes in the past, possibly created by water pockets eroding limestone and sandstone, though most of these features have likely collapsed due to their instability.

It currently produces auto parts, industrial machinery, commercial printing, plastics, food processing, electronics, tool and dies, concrete supplies, and fire engines.

It currently spans 15 miles (24 km) from its start in Grandville at Wilson and 28th where drivers gather and drive to the cruise's end in Cascade Township.

[31] Following the 2020 United States presidential election, MLive reported in 2022 that mayor-elect Kent Vanderwood was included among a Michigan contingent of Republicans allegedly involved in the Trump fake electors plot, reportedly organized as one of the attempts to overturn the 2020 United States presidential election in favor of incumbent President Donald Trump.

[95] On July 18, 2023, Mayor Kent Vanderwood, along with 15 other people statewide, was indicted by the Michigan Attorney General for his role in the 2020 fake electors plot.

[96] On September 30, 2007, Metro Health Hospital moved from southeast Grand Rapids to its current location on the south central section of Wyoming.

Garbage service is supplied by individual contractors to homeowners and by law they are required to use the county incinerator, although the city does provide a yard waste drop off center.