Wyoming Highway 431 is intersected at approximately 33 miles into the route, and it travels east along Gooseberry Creek to US 20/WYO 789 located southwest of Worland.

After leaving Meeteese, WYO 120 intersects no other state highways until it reaches Cody.

It intersects the multiplexed US 14/US 16/US 20 (Greybull Highway) at the foot of Yellowstone Regional Airport.

After encountering WYO 296, Highway 120 turns to start heading in a north-northeast direction.

At 113.83 miles, WYO 120 intersects the Former Wyoming Highway 292 (Clarks Fork Canyon Road).

Wyoming Highway 120 reaches the Montana-Wyoming State Line at 121.96 miles and ends.