It then descends and passes through the community of Wilson, a census-designated place (CDP) west of Jackson.

On the eastern border of Wilson, at 13.51 miles (21.74 km), WYO 22 intersects the southern terminus of Wyoming Highway 390 (Moose-Wilson Road) before crossing the Snake River.

[citation needed] On June 8, 2024, WYO 22 suffered a “catastrophic” failure when a portion of the road collapsed in a landslide at milepost 12.8 (43°30′13″N 110°58′32″W / 43.5035°N 110.9756°W / 43.5035; -110.9756 (Landslide Site)), less than five miles (8 km) by air from the Idaho border.

[2] A 600-ft detour, constructed by a contractor of the Wyoming Department of Transportation, was opened to traffic on June 28, 2024.

[3] The detour has a sharper curvature and a grade of 11.2 percent (the original road built in the 1960s had a 10 percent grade), with a reduced speed limit of 20 mph, but the former 60,000 lbs gross vehicle weight restriction remains.