Wyoming Highway 252 (WYO 252) is a 4.37-mile-long (7.03 km) Wyoming state road in Natrona County, serving the areas just south of the City of Casper.

It is locally known as Garden Creek Road from WYO 251 to the Casper city line where it becomes South Poplar Street.

Highway 252 proceeds southwest for a just under a mile before turning west.

However, one mile later WYO 252 turns again, this time north as it crosses Garden Creek for which it is named after.

[2] Highway 251 now will roughly parallel Garden Creek for the remainder of its routing to Casper.