The southern terminus of WYO 251 lies on the Casper Mountain summit at an elevation of 8,485 feet and provides access to the Hogadon Ski Area.

[2] Natrona CR 505 continues southwest of the Casper Mountain area and meets County Route 401, which links to Wyoming Highway 487.

At the base, the southern terminus of Wyoming Highway 252 (Garden Creek Road) is intersected at just under 4 miles.

[1][3] Highway 251 continues northward and changes names to South Wolcott Street.

The northern terminus of Highway 251 lies at the business routes of I-25/US 20/US 26/US 87 (E. 1st Street) in Casper.