Wyoming Highway 270 starts at its southern end in Platte County at US 26 on the eastern edge of Guernsey.

WYO 270 reaches Hartville at approximately 4.5 miles, and intersects the western terminus of Wyoming Highway 318 (Main Street).

[1] Wyoming Highway 270 then begins to turn east as the last length of its routing is primarily east–west.

At just over 73 miles, WYO 270 reaches its northern (or eastern) end at US 18/US 85 north of Lusk.

Highway 318 used to begin as US 26 at Guernsey and end at Sunrise with a 90 degree turn at Hartville.