Wyoming Highway 259 (WYO 259) is an 18.00-mile-long (28.97 km) north-south state highway located in northeastern Natrona County, north of Casper, in the east-central part of the U.S. state of Wyoming.

Wyoming Highway 259 begins its southern end at an interchange with I-25/US 87 (Exit 210).

[2] Highway 259 heads north 18.00 miles (28.97 km) to the Town of Midwest just east of the Town of Edgerton.

[3] Here WYO 259 comes to an end at Wyoming Highway 387 near the Salt Creek Oil Field.

[2] Highway 259 is the fastest route for travelers between Casper and Midwest.