Wyoming Highway 351 (WYO 351) is a 24.18-mile-long (38.91 km) east-west Wyoming state road located in central Sublette County.

It connects U.S. Route 189 (US 189) with US 191 and mainly serves the hugely important Big Piney-Rock Springs corridor.

[2] Wyoming Highway 351 begins its western end east of the Big Piney-Marbleton Airport at U.S. Route 189, 2 miles north of Marbleton and 3 miles north of Big Piney.

[3] Highway 351 travels east and crosses the Green River at 7.30 miles (11.7 km) and shortly after intersects Sublette CR 110 and 175.

[4] Now WYO 351 runs along the north side of the New Fork River, a tributary of the Green River, and parallels it for a few miles before crossing it at approximately 12.90 miles (20.8 km).