Wyoming Highway 352 begins its southern end at U.S. Route 191, 5 miles west of Pinedale.

Highway 352 travels north, reaching the community (CDP) of Cora at just over 4 miles.

Past Cora, WYO 352 begins to parallel the New Fork River, and will do so for approximately 7 miles.

Just north of Cora, Forty Rod Road (CR 149) is intersected at 7.79 miles (12.5 km).

[2][3] Highway 352 reaches its northern terminus at the entrance Bridger National Forest at 25.31 miles.