Wyoming Highway 376 (WYO 376) is a 4.31-mile (6.94 km) state highway in southern Sweetwater County, Wyoming, United States, that forms a loop off of the south side of the city of Rock Springs.

WYO 376 travels counterclockwise from west to east around the southern edge of Rock Springs.

(I-80 BL/US 20 Bus./Dewar Drive) southeast around the southern end of Rock Springs (briefly leaving the city limits), and turns back north as it nears Wyoming Highway 430 (WYO  430).

[2] WYO 376 formerly continued in a counterclockwise direction from its current eastern terminus to connect back to the former U.S. Route 187 (Elk Street).

However, Wyoming Department of Transportation (WYDOT) maintains the section of Elk Street between I-80 BL/US 20 Bus.