WYO 412 begins at a diamond interchange on Interstate 80 in northeastern Uinta County, northwest of Lyman.

The route is a continuation of WYO 414, which proceeds southward through Urie and Mountain View.

[3] From I-80, WYO 412 proceeds in a northwestward direction, passing the Fort Bridger Airport.

After about 8 miles (13 km), it reaches the community of Carter, where it crosses a Union Pacific rail line.

From there, it proceeds another 14 miles (23 km) northwest, crossing into Lincoln County before ending at U.S. Highway 189.