Wyoming Highway 487 (WYO 487) is a 71.56-mile-long (115.16 km) state highway in northeastern Carbon County, Wyoming and southeastern Natrona County, Wyoming that runs from its south end at US 30/US 287 to a north end at WYO 220.

Wyoming Highway 487 begins its south end at US 30/US 287 (Old Lincoln Hwy.)

WYO 487 travels north towards Shirley Basin and intersects WYO 77 at 22.1 miles (35.6 km), that route's southern terminus.

WYO 487 travels another 27 miles (43 km) to its north end at Wyoming Highway 220 which is located 11 miles (18 km) NE of Alcova and 19 miles (31 km) SE of Evansville.

[1] The Medicine Bow–Casper Cutoff was designated as Highway 487 by the Wyoming Highway Commission in March 1959.