WYO 50 heads due north, named 4J Road,[1] and passes through the community of Savageton.

Eighteen miles north of Savageton, Highway 50 turns and runs southwest to northeast until it reaches Gillette.

Highway 50 continues north-northeast into Gillette, intersecting Interstate 90 (Exit 124) and the south end of I-90 Business.

[2] According to a 1980 Wyoming state map, WYO 50 was formerly routed along 4J Road into Gillette.

Sometime between 1980 and 1993, WYO 50 was moved from 4J Road to Skyline Drive, which provides easier access to Interstate 90.