At approximately 38.5 miles (62.0 km) or halfway to Wright, WYO 59 passes through Bill, an unincorporated community in Converse County.

From Wright to Gillette there are no intersections with major highways and the landscape consists of buttes covered with short grasses.

[3] A few miles north of Gillette, WYO 59 ends its concurrency with US 14/US 16 at a three-way intersection east of Rawhide Elementary School.

Weston is an unincorporated community in northern Campbell County, along the upper Little Powder River on the southeastern edge of the Thunder Basin National Grassland.

For the rest of the way through Campbell County, WYO 59 parallels Little Powder River that lies to the highway's east all the way to the state line.

[6] Highway 59 carried significant truck traffic from oil fields, which caused noticeable damage on rural sections as well as congestion in Douglas.

[7][8] As oil and coal extraction in the Powder River Basin increased in the early 2010s, WYDOT drafted plans to add additional passing lanes and install rumble strips on WYO 59.

The increase in fatal collisions prompted the state government to accelerate $21.2 million in funding for safety improvements at the expense of projects in other regions.

[10] The Casper Star-Tribune editorial board called WYO 59 the "highway of death" as well as the Powder River Basin's "central corridor" and supported funding the improvements.

[12] The Teton County Commissioners voted in 2015 to ask that the state divert $30 million in funding earmarked for expansion of US 89 in the area to safety improvements on WYO 59.