Wyoming Highway 78 (WYO 78) is a 1.23-mile (1.98 km) long Wyoming state highway located in Carbon County in the city of Rawlins.

The highway runs along a portion of South Higley Boulevard.

Wyoming Highway 78, albeit short in length, serves as a connection between Highway 71, Interstate 80, and U.S. Route 30 at exit 214, and the Wyoming State Penitentiary to the south.

[2] Mileposts increase from north to south along Highway 78.

The entire route is in Rawlins, Carbon County.