As with most X-linked disorders, males are more heavily affected than females.

Unlike many other types of intellectual disability, the genetics of these conditions are relatively well understood.

[4] Many of these genes are found on the short 'p' arm of the chromosome, and duplications at Xp11.2 are associated with the syndromic form of the condition.

[7] Several X-linked syndromes include intellectual disability as part of the presentation.

These include: Following is a list of genes located on the X chromosome and linked to intellectual disability.