Yellapragada S. Chandrashekhar (born April 30, 1960) is an American cardiologist and Professor of Cardiology at the University of Minnesota.

He was one of the first researchers to describe adult subacute mountain sickness.

Following that, he spent several years at the Post Graduate Institute in Chandigarh, India, where he published extensively.

Chandrashekhar was chair of the Cardiology Merit Review study section of the VA and is on the Scientific and Policy Advisory Committee of the World Heart Federation.

He was also an author of the 2015 multimodality imaging guidelines in COCATS 4 and has published extensively in medical journals.