[1] Since 2015, each issue covers a particular topic in biology, medicine, or public health, including experimental and clinical research.

The journal's editorial board is composed of Yale University graduate, medical, and professional students.

It is published on PubMed Central and is financially supported by the Yale Office of Medical Education.

During his tenure, Winternitz instituted what became known as "The Yale System of Medical Education", which eliminated required course exams and comparative grades, allowed for flexibility of course requirements in students' schedules, and encouraged students to carry out original thesis research and writing.

[6] The journal also creates a series of podcasts with discussions with editors, authors, and Yale faculty researchers and clinicians.