Born in Montélimar, Drôme, Jouffre made his professional debut for Nîmes Olympique on 23 January 2002, coming on as a substitute for Christophe Van Reusel in a 0–0 draw with FC Istres.

Jouffre had his breakout year the next season making another 32 appearances and scoring four goals, earning himself a transfer to Ligue 1 side En Avant de Guingamp in the summer of 2003.

In January 2008, Jouffre signed for Ligue 1 club FC Lorient, after 116 appearances for Guingamp, for an undisclosed fee.

The 2011–12 season saw Jouffre return to form he had not had for a few years as he marauded up and down the right flank for Lorient, scoring three goals and managing a further seven assists in 30 Ligue 1 appearances.

On 11 June 2016, it was announced that Jouffre had signed for newly promoted Ligue 1 club Metz after eight seasons with Lorient.