They are the most mysterious of all the Monodelphis that is found specifically in the Pampean region or Pampa of Argentina.

It is suspected to be a once-in-a-lifetime breeder as seen in a three-year observational study of one population in the marshy grasslands of the Pampean region.

Both males and females hunt insects and small vertebrates, and show specialized behaviors for dealing with difficult prey.

[4] Small mice are rapidly chased and attacked until a firm bite at the neck is attained, similar to the throat clamp used by large carnivores.

Like extinct sabertooth predators, it has one of the largest canines of any marsupial relative to body size and was proposed as a living model to test hypotheses about hunting strategies of the extinct predators.