It is situated in the famous West-end Synagogue; the current bochurim (rabbinic students) come mainly from Israel and the United States.
The Yeshivah Gedola was the first orthodox Yeshiva that was established in Germany after World War II (see also Rabbinerseminar zu Berlin).
In a certain sense it continues the tradition of what once Germany's largest yeshiva, Torah Lehranstalt, which was organized in Frankfurt by Solomon Breuer, son-in-law and successor of Rabbi Samson Raphael Hirsch.
In October 2023, the yeshiva reopened after being closed for several years before due to the COVID- 19 pandemic.
It reopened in a new format with bochurim from Oholei Torah, with special emphasis on the Chabad outreach programs in the Jewish Community in Frankfurt and the surrounding areas.