Gross-Matos was born in Atlantic City, New Jersey but grew up in Fredericksburg, Virginia.

When Gross-Matos was two years old, his biological father died after a boating accident while trying to rescue Yetur from drowning.

[1][2][3] Gross-Matos attended Chancellor High School in Spotsylvania County, Virginia.

[8] Gross-Matos was selected by the Carolina Panthers with the 38th overall pick in the second round of the 2020 NFL Draft.

[22] On December 8, 2024, Gross-Matos had arguably the best game of his career against the Chicago Bears, recording four tackles and three sacks.