[12] The record was set at the 2007 CARIFTA Games held in the Turks and Caicos islands where he was also a member of the winning 4x100m relay team.

He proved himself to be a serious competitor at the senior level: he took third place behind Tyson Gay and Asafa Powell and improved his personal best with a 10-second barrier-breaking run of 9.96 seconds,[18] becoming the youngest athlete ever to do so.

[19] He improved to 9.93 seconds shortly after, taking third place behind training partners Bolt and Daniel Bailey at the Meeting Areva.

[20] Prior to the 2009 World Championships, Blake (along with Marvin Anderson and Sheri-Ann Brooks) tested positive for the stimulant 4-methyl-2-hexanamine.

However, JADCO appealed their own panel's ruling, stating that the athlete should be disciplined as the drug was similar in structure to the banned substance tuaminoheptane.

[23] As the panel would resolve the issue after the World Championships, the Jamaica Amateur Athletic Association took the precaution of withdrawing Blake from the relay race.

[29][30] At the 2011 IAAF Diamond League meeting in Zurich, Blake beat Asafa Powell in the 100 m with a personal best of 9.82 seconds.

[31][5] In this particular race, his reaction time was relatively slow (0.269 s) and had he made even an average start, he could have comfortably set a new world record.

[34] In the 4×100 m final, Blake ran the third leg as the Jamaicans won gold, setting a new world record time of 36.84 seconds.

He then suffered another hamstring injury and fell at the 40 metre mark during the Glasgow Diamond League 100 m race shortly after that, ending his season.

[36] Blake made a strong comeback in 2016, running his first sub-10 race since 2012—a 9.95 s in the 100 m at the 2016 Kingston MVP Track and Field meet.

[citation needed] At the 2017 World Championships in Athletics in London, Blake finished in fourth place yet again in the 100 m final.

This time, he clocked 9.99 seconds, just 0.04 behind Usain Bolt, who failed to win his last individual race and instead settled for bronze.

Just as he did in Rio the previous year, Blake failed to progress into the 200 m final, though he was ranked closer this time with 11th overall and a slower 20.52 s to come third in his heat.

After this, Blake looked forward to the Men's 4 × 100 metres relay, his last chance at a medal at the championships, and Usain Bolt's final race.

However, he stumbled out of the blocks in the final, and despite his strong efforts to recover, he ultimately placed third in 10.19 seconds, behind Henricho Bruintjies and Akani Simbine of South Africa.

[citation needed] In January 2019, coach Glen Mills reported that he had parted ways with Blake after a disagreement.

Months later, Blake and numerous former members of Racers Track Club accused Mills of favoring Usain Bolt.

On 2 May, Blake reached sub-ten performance clocking 9.98 seconds at the National Training Centre, Clermont, USA.

[16] Playing for the Kingston Cricket Club in the athletics off-season and specialising as a bowler, Blake once took four wickets for ten runs.

[16] On 16 August 2012, Blake rang the bell at Lord's Cricket Ground, London to signify the start of the third Investec test match between England and South Africa.

[citation needed] Blake is also a fan of the IPL team Royal Challengers Bangalore (RCB) and has expressed his desire to play for them[41] and for Yorkshire County Cricket Club.