Yokena is an unincorporated community in southern Warren County, Mississippi, United States.

It is bordered to the south by the Big Black River, to the north by Warrenton, to the east by Campbell Swamp, and to the west by U.S. Highway 61.

Yokena Presbyterian Church was organized on May 11, 1884, and was built on land that was part of a Spanish land grant and given by Mrs. Patty Hyland Gould Hankinson.

The first pastor, the Reverend Charles Pier Colmery, served from 1888 until his death in 1938.

The climate in this area is characterized by relatively high temperatures and evenly distributed precipitation throughout the year.