Yona Kesse (Hebrew: יונה כסה, 15 October 1907 – 27 June 1985) was an Israeli politician who served as a member of the Knesset between 1949 and 1965.

Born in Dobre [uk] in the Russian Empire (today in Ukraine), Kesse was educated at a heder.

He was a member of HeHalutz, which was an illegal organisation in Russia, and in 1925 he was arrested for Zionist activities.

Kesse joined Hapoel Hatzair, and in 1932 became secretary of Rehovot Workers Council.

On 22 December 1964, he resigned from Mapai and became an independent MK; his attempt at forming a single-member faction by the name of Min HaYesod, being rejected by the House Committee.