Yosef Serlin (Hebrew: יוסף סרלין, 24 February 1906 – 15 January 1974) was a Zionist activist, lawyer and Israeli politician.

Serlin was born in Białystok in the Russian Empire (now in Poland), where he attended a Hebrew High School.

He was a member of the House, Labor, Constitution, Law and Justice, Economic Affairs, and Finance Committees.

He sought to strengthen the national control over the health system at the expense of the Israel's sick funds.

[2] He was a hawkish minister, and Moshe Sharett wrote in his diary that Serlin had asked him in 1954 to attack the Gaza Strip in reprisal to the Palestinian Fedayeen insurgencies.