The El Adobe de los Robles Rancho built by pioneer Daniel Rhoads can be found north of Lemoore.

Southeast of Caruthers, SR 41 becomes a four-lane divided highway and eventually a freeway approaching the Fresno city limits.

North of Fresno, the route crosses the San Joaquin River, and enters Madera County near Valley Children's Hospital before reverting to a two-lane highway.

As SR 41 had not been signed over the unpaved road west of Paso Robles, it was truncated to Cholame.

[17][18] In the 1980s, the urban stretch of 41 running through Fresno was upgraded to freeway standards, intersecting SR 99 to the south.

Also in the late 1990s and early 2000s in Atascadero, the old SR 41 alignment used to cut through downtown by going north on El Camino Real and turning right onto West Mall.

Then Caltrans built a bypass of this dangerous route with a long wider bridge crossing the railroad, Sycamore Drive, and the river before joining the original 1950s SR 41.

In February 2024, Caltrans closed a portion of SR 41 near Stratford in a project to replace the 1947 Kings River bridge, forcing a 32 mi (51 km) temporary detour.

Developers are interested in building distribution warehouses in Kings County because of its strategic location midway between the Los Angeles and San Francisco Bay areas, but they are currently turned off by the lack of freeway access.

For SR 41, the plan is to upgrade it so the highway is a continuous freeway from I-5 north to Fresno County.

However, Kings County voters have shown little interest in passing any transportation taxes to fund these projects.

[20] Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage.