The antiquarian and copyist of Welsh manuscripts John Jones (c.1585-1657/8) was born and brought up in the small mansion of Gellilyfdy in Ysceifiog parish.

Thomas Wynne (1627–1692) was born in Ysceifiog, where his family dated back seventeen generations to Owain Gwynedd.

Wynne became personal physician to William Penn and was one of the original settlers of Philadelphia in the Province of Pennsylvania.

The local football team, Ysceifiog F.C., joined the Llandyrnog and District Village Summer League in 1976.

Although taking the name of the village Ysceifiog Wolves JFC, a successful junior league football team coming runners up in the Tesco UK Championships in 2011.