She entered the adult entertainment industry in 2015 under the Muteki label and became one of the most popular and best-selling contemporary AV idols, winning several awards in the process.

[3] In 2023, at the height of her popularity, Mikami retired from the AV industry and continues her career as a social media influencer and a businesswoman.

[5] In March 2009, she debuted as a second generation member of the idol group SKE48 on Team E. Her career in SKE48 saw numerous setbacks, including a demotion to kenkyuusei (trainee) status in December 2010,[6] as well as an underage drinking/dating scandal that broke out in July 2013.

[11][12] The unexpected positive reaction of her debut motivated Mikami to remain in the industry as an active performer.

[20] Mikami's popularity continued to grow, as she became one of S1's "flagship" actresses, with her films regularly appearing on the best selling charts.

[26] Mikami also appeared in S1's 15th-anniversary special, along with the studio's other exclusive performers: Tsukasa Aoi, Ayami Shunka, Moe Amatsuka, Arina Hashimoto, Usa Miharu, and Nene Yoshitaka.

In 2019 and 2020, according to Fanza, she became the second highest selling AV actress of the year next to Yui Hatano[28] and popular industry newcomer Ichika Matsumoto.

[32] However the group's debut proved to be controversial due to the member's line of work which went against the "pure" image associated with Korean idols.

[33][34] Due to the intense backlash Matsuda left Honey Popcorn in December 2018, but Mikami managed to revive the group with three new members, and they released their second EP, De-aeseohsta in July 2019.

[35] In the same year, Mikami also started her own clothing brand, "YOUR'S" (later rebranded as "miyour's", now “MISTREASS”), a career choice largely inspired by her close friend and AV idol Kirara Asuka.

[36] On June 27, 2020, Mikami guest starred in Malaysian singer-songwriter Namewee's new music video titled "I Shot You" (Chinese: 不小心).

In July 2013, while she was a member of SKE48, Shūkan Bunshun published pictures of her kissing Yuya Tegoshi, while being allegedly drunk, and staying overnight at his house in May 2013.