Syedna Yusuf Najmuddin Bin Syedna Zakiuddin[1] (Arabic: يوسف نجم الدين) (died on 18 Jumadil Ukhra 1213 AH/27 November 1798 AD, Surat, India) was the 42nd Da'i al-Mutlaq (Absolute Missionary) of the Dawoodi Bohra sect of Musta‘lī Islam.

He succeeded the 41st Da'i Abduttayyeb Zakiuddin Bin Badruddin, to the religious post.

He was born in Jamnagar in 1764 AD and was tutored by his father Syedna Abduttayyeb Zakiuddin Bin Badruddin.

In 1204 AH, he visited Ahmedabad and initiated restoration of graves and mausoleums of previous Dais.

On route to Surat, he briefly stayed in Pune during the tenure of Peshwa Madhavrao II.