Syedna Abduttayyeb Zakiuddin (died 2 Rabi-ul-Awwal 1041 AH/1633 AD; born 8 Safar-ul-Muzaffar 972 AH/15 September 1564 AD, Ahmedabad, India) was the 29th Da'i al-Mutlaq of the Dawoodi Bohra.

He succeeded the 28th Dai, Syedna Sheikh Adam Safiuddin to the religious post.

He had two brothers: 32nd Dai Syedna Qutub Khan Qutubuddin, Miya Khan-ji and a sister called Habiba.

It was during his tenure that a dissident sect was formed called Alavi Bohras led by Ali bin Ibrahim, grandson of Syedna Sheikh Adam Safiuddin.

The inner walls are ornamented with verses of the Quran in Kufic script and inlaid with rubies.