He became well known for his roles in the popular Israeli TV show, Eretz Nehederet and later for Zanzouri and Hashoter Hatov (The Good Cop).

[1] He began his acting career as part of the "Prozac Trio" (שלישיית פרוזאק) with whom he participated in many Israeli TV shows such as "Eretz Nehederet", "Ha-Retzu'a","Ha-Chaim Ze Lo Hacol", "Shidurey HaMahapecha", "Domino", "Naor's Friends" and "HaPijamot".

He also played secondary roles in several Israeli films such as "Bekarov, Yikre Lekha Mashehu Tov", "Yossi and Jagger" and "Zohi Sdome".

In 2007 he joined the cast of the Israeli television show "Eretz Nehederet" (Hebrew: ארץ נהדרת, lit.

Among the characters whom Semo memorably parodied were political commentator Ehud Yaari, musician Moshe Ben-Ari, politician Isaac Herzog, Hezbollah leader Hassan Nasrallah, Israel Minister of Justice Daniel Friedmann, Israel Attorney General Menachem Mazuz, Israeli politician Uri Orbach and the Queen of the United Kingdom.