In addition to television, she has had supporting roles in films such as (500) Days of Summer, Tropic Thunder, Repo Men, Percy Jackson: Sea of Monsters, and Avengers: Endgame.

She voiced Harper in the video game Minecraft: Story Mode in addition to Cookie on Pound Puppies, Luna on Elena of Avalor and Principal Amanda Waller on DC Super Hero Girls.

[5] Brown appeared as "Yvette" in the music video "1-4-All-4-1" by the East Coast Family, a Michael Bivins project, for Biv10 Records.

On September 30, 2014, Brown announced that she would be leaving the show after five seasons in order to take care of her ailing father.

"[9] She has appeared in television commercials for Hamburger Helper, Big Lots, Pine-Sol, Comcast, Aquapod, Shout, Fiber One, Yoplait Yogurt, DiGiorno Pizza, Dairy Queen, and Time Warner.

[8] She has appeared on episodes of The Thrilling Adventure Hour as "The Troubleshooter" in the Sparks Nevada, Marshall on Mars series.

In 2012, Brown appeared as a celebrity contestant on GSN's The Pyramid with her Community co-star Danny Pudi.

[10] Shortly after her exit of Community, Brown's role of Dani on the CBS sitcom The Odd Couple was upgraded to series regular.

[14] She later competed in season twelve as "Showbird" with recurring panelist Joel McHale as her Mask Ambassador.

[15] In 2023, Brown voiced KRS, a robotic assistant, and recurring character in My Dad the Bounty Hunter.