The middle sister of three, she was married to French military officer Alphonse Emil Alfred Latrique for a few years.
Later, divorced, she met and fell deeply in-love with Gabriel Roche, a successful urban developer during the rebuilding years of France after World War II.
She most notably played the role of Madame Lajoie in François Truffaut's Academy Award for Best Foreign Language Film winner, Day for Night (1973) (originally billed as La Nuit américaine, France) for which Truffaut was also nominated for the Academy Award for Best Director.
She played the role of Madame Pouche in Philippe Ducrest's television programme Chambre 17 (1981), as well as an "old woman" in the mini-television-series A Year in Provence (1993).
On 28 October 2005, Zénaïde Rossi Roche passed, survived at that time by her two youngest sons.