ZNF816

The product protein of the ZNF816 gene is 651 amino acids in length, with a predicted molecular weight of 75.7 kDa and an isoelectric point of 9.44.

This domain suppresses transcription by recruiting co-repressor proteins, which create heterochromatin, blocking RNA polymerase from accessing the gene.

The tertiary structure of ZNF816 was predicted by iTasser[10] and annotated (Icn3D[11]) according to the characteristics of other zinc finger proteins and prominent domains.

In normal tissues, it shows moderate to high mRNA levels, suggesting consistent transcriptional activity.

[18] These paralogs likely maintain similar roles in transcriptional regulation, reflecting the conserved functions characteristic of zinc finger proteins.

The closest ortholog is found in the bonobo (Pan paniscus), with 88.8% identity,[18] indicating strong conservation within the Hominidae family.

While ZNF816 is not present in non-mammalian species, distant homologs containing its zinc finger domains can be found in other vertebrates, including birds and fish.

Ideogram of human chromosome 19 [ 4 ]
AlphaFold predicted secondary structure of ZNF816
iTasser predicted tertiary structure of ZNF816 with annotated KRAB domain, disordered regions, and C2H2 Zn fingers
Phylogenetic tree of ZNF816 in humans and orthologs, identified by species name abbreviations [ 17 ] .
ZNF816 Evolutionary History comparing median Date of Divergence from Homo sapiens (millions of years) and Corrected Sequence Divergence for ZNF816, Cytochrome C, and Fibrinogen Alpha.