In 1499 he helped bring out the Etymologicum Magnum in Venice[1] and in 1515 he set up a printing press where he published exclusively Greek volumes, among them the first Greek book printed in Rome, Pindar's Epinikion ("Victory Odes").
He also instituted the Greek College of the Quirinal [el] (Gymnasium Caballini Montis) where lectures were given, by among others, eminent fellow Cretan scholar Marcus Musurus and Janus Lascaris.
The printery was exclusively staffed by Cretans, both in technicians and in individuals who shouldered the literary responsibilities of the publications.
The offspring of this Cretan collaboration were four archetypes: the Etymologicum Magnum, one of the most important Byzantine dictionaries, the Ypomnema eis tas dekas kategorias tou Aristotelous, the Ypomnema eis tas pente phonas Porphyriou, tou Ammoniou and the Therapeutica of Galen.
The publications are characterized by Byzantine luster, enriched by the expanded use of red-types, and aesthetic titles, and different sized first letters.