She has graced the covers of almost all Pakistani magazines, and appeared in campaigns for almost all leading brands, including Deepak Perwani, Aasia Saail, Salina Wardah, Nee Punhal, Dawn Bread, Mobilink, Rite Biscuits, Golden Chips, Coca-Cola, Head & Shoulders, Dabur Amla, 7up, Meezan, Gul Ahmed, Nishat, Levi's, Crossroads, and Lajwanti, to name a few.

[citation needed] Unlike most Pakistani models, her fashion career, despite entering movies in 2000, continued for a long time owing to get ability to totally transform for each shoot.

Zara Sheikh made her cinema screen debut in 2000, through film director Hassan Askari's Tere Pyar Mein, in which she played the role of an Indian Sikh girl, who falls in love with a Pakistani banker.

A year later, in 2003, Sheikh played the part of a Hindu girl, Ram Khori, who converts to Islam, in Laaj (means Honour in English), a love tale set in the backdrop of 1947 partition of India and Pakistan.

[3] In 2002, Zara Sheikh collaborated with Ali Haider to playback sing three musical numbers for her movie Chalo Ishq Larain.