He is known for his work at Marvel Comics, as well as being a writer, director, and voice actor on the Adult Swim animated series Robot Chicken.

[7] He wrote twenty of the first twenty-one issues of the third volume of New Mutants, a series he launched with artist Diogenes Neves, including a tie-in to the "Necrosha" storyline.

[11] In April 2022, Wells took over as lead writer for The Amazing Spider-Man along with artist John Romita Jr.[12] The book was relaunched with a new #1 after the Beyond storyline, making it the sixth new #1 for the title.

In 2023, Wells claimed that Marvel Editorial warned him not to attend any comic conventions after the release of #26 due to a surprising plot twist in the issue (later revealed to be the death of Ms.

[14] Andrew Cutler of Comic Book Resources claimed that the series "needs a course correction" and that "the creative team must make changes to improve the overall quality of the storytelling".