Zenobia e Radamisto is an opera in 3 acts and nine scenes by composer Giovanni Legrenzi.

The third opera written by Legrenzi, the work premiered on 1 June 1665 at the Teatro Bonacossi in Ferrara in celebration of the marriage of Nicolò Santini and Maria Luisa Bonvisi.

[3] Legrenzi revised the work for the Venice premiere of the opera at the Teatro San Salvatore on 26 December 1667.

The revised opera also utilized an altered version of Bentivoglio's libretto by Nicolò Minato.

[1] In 2013 the Italian Academy of Musical Research published the original 1665 version of the libretto and the first critical edition of the score.