Zhongxiniscus is a genus of primitive chordate from eastern Yunnan that lived during the Early Cambrian.

Known from a single specimen, it had a small, broad and short, fish-like body that was roughly ten millimeters in length.

It possessed S-shaped myomeres, numbering roughly seven per one millimeter of length.

When compared to other Cambrian chordates like the possible cephalochordate Cathaymyrus and the two known vertebrates Haikouichthys and Myllokunmingia, Zhongxiniscus resembles Cathaymyrus in having S-shaped myomeres, but is different in having a dorsal fin and a shorter body.

For these reasons, Zhongxiniscus is tentatively considered to be an intermediate form between Cathaymyrus and the two vertebrates Haikouichthys and Myllokunmingia.