[5] The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression.

This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells.

Several transcript variants have been found for this gene, but only one of them is protein-coding.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 22 is a stub.