Princess Zofia Ostrogska (Lithuanian: Zofija Ostrogiškaitė; 1595–1622) was a Polish–Lithuanian noblewoman of Ruthenian origin, known as the heiress of one of the greatest fortunes in Poland.

She was the wealthiest woman in Poland.

She married Stanisław Lubomirski in 1613.

[1] Through this marriage he became an owner of 18 towns, 313 villages and 163 granges in the provinces of Kraków, Sandomierz, Ruthenia and Volhynia.